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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB1
All Species:
45.76
Human Site:
Y681
Identified Species:
77.44
UniProt:
P08238
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08238
NP_031381.2
724
83264
Y681
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
Y690
Q
T
H
A
N
R
I
Y
R
M
I
K
L
G
L
Rhesus Macaque
Macaca mulatta
XP_001098520
724
83571
Y681
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
Y681
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Rat
Rattus norvegicus
P34058
724
83263
Y681
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
T767
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
Chicken
Gallus gallus
Q04619
725
83409
Y682
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Frog
Xenopus laevis
NP_001086624
722
82939
Y679
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Zebra Danio
Brachydanio rerio
O57521
725
83339
Y680
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
Y674
Q
V
H
A
S
R
I
Y
R
M
I
K
L
G
L
Honey Bee
Apis mellifera
XP_395168
718
82735
Y677
Q
V
H
A
A
R
I
Y
R
M
I
K
L
G
L
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
Y659
Q
S
H
A
S
R
I
Y
R
M
I
K
L
G
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P27323
700
80617
H662
N
T
F
A
A
R
I
H
R
M
L
K
L
G
L
Baker's Yeast
Sacchar. cerevisiae
P02829
709
81388
N669
T
S
F
A
S
R
I
N
R
L
I
S
L
G
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86
95.1
N.A.
N.A.
99.1
99.5
N.A.
86.8
94.7
92.4
91.4
N.A.
78.4
81.3
75.4
N.A.
Protein Similarity:
100
93.4
96.1
N.A.
N.A.
99.5
99.8
N.A.
87.5
97.7
96.6
97
N.A.
88.5
89.9
86.8
N.A.
P-Site Identity:
100
93.3
100
N.A.
N.A.
100
100
N.A.
0
100
100
100
N.A.
80
80
80
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
26.6
100
100
100
N.A.
93.3
86.6
100
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
69.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
83.8
78.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
43
15
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
93
0
% G
% His:
0
0
79
0
0
0
0
8
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
93
0
0
0
86
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
86
0
0
0
% K
% Leu:
0
0
8
0
0
0
0
0
0
8
8
0
93
0
93
% L
% Met:
0
0
0
0
0
0
0
0
0
86
0
0
0
0
0
% M
% Asn:
8
0
0
0
58
0
0
8
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
79
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
93
0
0
93
0
0
8
0
0
8
% R
% Ser:
0
22
0
50
22
0
0
0
0
8
0
8
0
0
0
% S
% Thr:
8
65
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
79
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _